Kimchi (Korean fermented vegetable) attenuates liver damage through improving lipid metabolism and suppressing apoptosis in high cholesterol diet-fed mice (2024)


2nd International Conference on Food Chemistry & Nutrition

July 24-26, 2017 Vancouver, Canada

Minji Woo, Mijeong Kim, Serim Kim, Jeong Sook Noh and Yeong Ok Song

Pusan National University, Republic of Korea
Tongmyong University, Republic of Korea

Posters & Accepted Abstracts: J Exp Food Chem

Abstract :

High cholesterol diet (HCD) is known to cause hepatic steatosis. Apoptosis is a major cell death pathway hepatocyte which occursin a wide variety of liver diseases. Kimchi, a Korean traditional fermented vegetable, demonstrated to have antioxidative, antiatherogenic,and anti-cancer properties. This study investigated whether kimchi methanol extracts (KME) affects lipid metabolismand apoptosis in the liver of HCD-fed mice. Animals fed HCD for 8 weeks with oral administration of KME (200 mg/kg bw/day) ordistilled water as a vehicle (n = 10 for each group). Compared with the control group, the kimchi group decreased the hepatic proteinexpression for fatty acid synthesis (SREBP-1, ACC�±, FAS) and cholesterol synthesis (SREBP-2, HMGCR), whereas increased thatfor fatty acid oxidation (PPAR-�±, CPT1, ACOX1) and cholesterol export (CYP7A1) (all for P<0.05). Additionally, hepatic proteinexpression for proapoptotic factors (Bax, p-JNK, caspase-3, -9) was decreased, while that for anti-apoptotix factors (Bcl2, cIAP) waselevated in the kimchi group (all for P<0.05). Furthermore, histological analysis (oil red O, H&E, TUNEL staining) in the liver tissueshowed that hepatic steatosis, inflammation, and apoptosis in the kimchi group were less severe. In conclusion, HCD-induced liverdamage can be alleviated by kimchi administration via improving lipid metabolism and suppressing apoptosis.

Biography :

Yeong Ok Song has completed her MS from California University and PhD from Pusan National University. She is now the professor of Dept. Food science and nutrition in Pusan National University. She has made reserach achievements, focusing on the lipid lowering and anti-atherogenic effects of functional foods, and kimchi in particular. She has published more than 50 papers for kimchi in reputed journals. Moreover, her excellence in research has been recognized by the Academic Society, by which she was awarded ‘The Greatest Achievement in Research in 2015.

Email: yosong@pusan.ac.kr

Kimchi (Korean fermented vegetable) attenuates liver damage through improving lipid metabolism and suppressing apoptosis in high cholesterol diet-fed mice (2024)

FAQs

Is kimchi bad for your liver? ›

Kimchi also helped sustain healthy liver function. Levels of AST and ALT, which are indicators of liver damage, were both lower in the kimchi group. Elevated AST and ALT levels are generally associated with damaged liver cells caused by hepatitis, fatty liver, and hepatocirrhosis.

Is kimchi bad for high cholesterol? ›

Probiotics may improve heart health by reducing cholesterol and inflammation. The fiber, antioxidants, and nutrients in kimchi can also help lower blood sugar and cholesterol levels, which can boost heart health. Early research suggests kimchi may strengthen your immune system.

What happens if you eat kimchi every day? ›

Numerous studies have shown that a diet high in fermented foods, such as kimchi, has proven health benefits, such as increasing microbiome diversity and reducing inflammation. Another study, published in April in the Journal of Ethnic Foods, found that kimchi can be an effective treatment aid for obesity.

Is eating kimchi good for skin? ›

Great For Your Skin And Anti-Ageing

Kimchi is high in vitamin C, which is responsible for collagen production. This protein keeps the skin youthful, maintains its firmness, reduces wrinkles, and slows the ageing process.

Who should not eat kimchi? ›

Another consideration is the high sodium content in kimchi. People at risk of high blood pressure might have concerns about the high salt content of this food.

What is the side effect of eating too much kimchi? ›

What happens when you eat too much kimchi? Since kimchi is fermented and spicy, you might experience uncomfortable gastric repercussions. Usually those with IBS or other gastrointestinal issues are more prone to sensitivity, especially since kimchi is also spicy.

What food lowers LDL the most? ›

Oatmeal, oat bran and high-fiber foods

Oatmeal has soluble fiber, which reduces your low-density lipoprotein (LDL) cholesterol, the "bad" cholesterol. Soluble fiber is also found in such foods as kidney beans, Brussels sprouts, apples and pears.

Is kimchi bad for gut health? ›

Along with fiber, vitamins, and minerals, kimchi contains natural probiotic bacteria. If you eat them regularly, the probiotics in fermented foods can be beneficial to your gut microbiome. Studies suggest that eating kimchi on a daily basis could help to improve some digestive problems.

Does kimchi increase inflammation? ›

In summary, fermented vegetables such as kimchi, sauerkraut, fermented soy products, and beverages such as fermented teas are garnering attention as a source of natural anti-inflammatory bioactive compounds.

How many times a week should I eat kimchi? ›

People who regularly eat the fermented vegetable dish kimchi — up to three times daily — may lower their risk of obesity. That's according to a study published today in the journal BMJ Open.

Is store-bought kimchi healthy? ›

Kimchi has an excellent nutritional profile. The dish is low in calories but packed with nutrients like iron, folate, and vitamins B6 and K.

Why does kimchi make me gassy? ›

The most common reaction to fermented foods is a temporary increase in gas and bloating. This is the result of excess gas being produced after probiotics kill harmful gut bacteria and fungi. Probiotics secrete antimicrobial peptides that kill harmful pathogenic organisms like Salmonella and E. Coli.

Does kimchi burn belly fat? ›

That saucy cabbage we know as kimchi may help you in your weight loss journey with a new study in BMJ Open suggesting that three servings of it in a day is linked to a lower rate of obesity, particularly abdominal or belly fat.

Is kimchi good for fatty liver? ›

Histological analysis of the liver tissue revealed a remarkable decrease of fat deposition in the kimchi group, compared with that in the control group (Fig. 1(A)). The concentrations of hepatic TG and TC in the kimchi group were lower than that in the control group by 26.34% (Fig. 1(B), p < 0.05) and 38.89% (Fig.

Does kimchi prevent aging? ›

Slows down the aging process

Koreans may have found the fountain of youth. Scientists have speculated that their famously smooth skin and youthful appearance may be attributable to their diet. Kimchi, with its high antioxidant content, may help slow down the process of aging.

Do fermented foods help the liver? ›

Kombucha is a fermented tea. Although more research is needed, animal and test-tube studies suggest that it could help protect the liver, decrease blood sugar, and lower cholesterol and triglyceride levels.

What Korean food is good for liver? ›

Well-fermented kimchi is sour, so is beneficial to the gallbladder and liver. Kimchi has vitamins A, B, and C but most importantly, it contains Lactobacillus, a probiotic similar to that found in yoghurt.

What are the 5 liver super foods? ›

Here are 10 of the best foods for liver health, and other tips for preventing liver disease.
  • 1. Fruits and Vegetables. istetiana / Getty Images. ...
  • Ginger. Armastas / Getty Images. ...
  • Garlic. SimpleImages / Getty Images. ...
  • Chia and Flax Seeds. Luis Echeverri Urrea / Getty Images. ...
  • Olive Oil. ...
  • Seafood. ...
  • Coffee and Tea. ...
  • Cacao Products.
Jan 9, 2024

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